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peak digoxin body stores of 8 to 12 mcg kg generally provide a therapeutic effect with minimum risk of toxicity in most patients with heart failure and normal sinus rhythm.
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oral verapamil may increase serum digoxin concentrations by 50-75 during the first week of verapamil therapy.
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in vitro data in human plasma indicate that cardura xl tablets have no effect on protein binding of digoxin, warfarin, phenytoin, or indomethacin.
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both men and women experienced significantly increased overall mortality with digoxin use.
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digoxin can rarely precipitate vasoconstriction and therefore should be avoided in patients with myocarditis.
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